進階篩選

Technical category
技術研發單位
    • A Manual CentrifugePaper Devices for Point-of-Care Diagnosis

      Precision Health Ecosystem FutureTech A Manual CentrifugePaper Devices for Point-of-Care Diagnosis

      Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.
    • Switch on a coming era to preservation of agricultural produce

      Precision Health Ecosystem FutureTech Switch on a coming era to preservation of agricultural produce

      To develop a potential preservative from microorganisms, Aureobasidium pullulans was the positive candidates. In a laboratory scale, we introduced the Aureobasidium pullulans broth into a practical delivery chain to simulate the commercial process. For disease severitybanana degreening, the results indicated we could obtain a better consistencylonger storage time for exports as well.
    • METHOD FOR LOWERING CANNIBALISM RATE IN FISH AND COMPOSITION

      Precision Health Ecosystem FutureTech METHOD FOR LOWERING CANNIBALISM RATE IN FISH AND COMPOSITION

      This technique used algae-a natural raw ingredient as novel functional aquafeed additives, as replacement for fish meal in nutrition sources, a fish oil replacement in the feed, an algae strain contains unsaturated fatty acid can change level of serotoninblood cortisol in fish brain, decrease their cannibalism rate. This technique can reduce feed production costincrease harvesting rate.
    • Precision blood test for detection of breast cancer

      Precision Health Ecosystem FutureTech Precision blood test for detection of breast cancer

      EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.
    • Intelligent Scalp Detection System

      Precision Health Ecosystem FutureTech Intelligent Scalp Detection System

      This system uses the innovative AIoT application to target annoying scalp maintenance problemsdevelops an intelligent scalp detectionmanagement system. The core of the technology is to use deep learning-based object detection models. Tens of thousands of microscopic image data sets that are labeledtrained for scalp symptoms. As a result, the scalp image recognition module is develop, such as dandruff, hair loss, oil, and inflammation, etc. Hence this system can provide scalp detection, and maintenance effectiveness tracking functions lead scalp maintenance services to a new level of intelligent management.
    • The comprehensive multi-tier long-term care delivery information platform

      Precision Health Ecosystem FutureTech The comprehensive multi-tier long-term care delivery information platform

      This project aims to incorporate the state-of-the-art InformationCommunication Technologies (ICT), the Internet of Things (IoT), Big Data techniques in linking every aspect of community-based integrated long-term care (LTC), improving the efficiency of care servicesadministrative process,to realize the idea of Aging in Place emphasized in the Long-term Care Policy 2.0 in Taiwan.
    • Heterocyclic compounds and use thereof

      Precision Health Ecosystem FutureTech Heterocyclic compounds and use thereof

      In this technology, a series of potent MOR/NOP agonists has been developed, which demonstrated potent antinociception in tail flick and cancer pain mouse models with fewer side-effects in respiratory suppression, heart rate decreasing, and constipation models than morphine.
    • BPRSJ338: Therapeutic Applications for COVID-19

      Precision Health Ecosystem FutureTech BPRSJ338: Therapeutic Applications for COVID-19

      BPRSJ338 exhibits high potency of anti-SARS-CoV-2 activity and is in development for fighting COVID-19 as a first-in-class drug. BPRSJ338 also potently inhibits against broad-spectrum coronaviruses including SARS-CoV-2, SARS-CoV, HCoV-229E, HCoV-OC43, TGEV, FIPV and MHV. Related US and Taiwan patents have been granted.​ Therefore it is also applicable to fight against severe evolving coronaviruses in the future.
    • DBPR807: a CXCR4-Targeted Antagonist

      Precision Health Ecosystem FutureTech DBPR807: a CXCR4-Targeted Antagonist

      DBPR807 can significantly suppress tumor growth, prevent distant metastasis, reduce angiogenesis, normalize tumor microenvironment and promote cytotoxic T-cell infiltration. In various HCC models, DBPR807 itself can prolong overall survival as effectively as marketed anti-angiogenic agent sorafenib and immune checkpoint inhibitor anti-PD-1 Ab. What’s more, its combination therapy with either sorafenib or anti-PD-1 Ab can extend life expectancy even more significantly than aforementioned monotherapy.
    • A Kinase Inhibitor that Induces Degradation of MYC Oncoprotein

      Precision Health Ecosystem FutureTech A Kinase Inhibitor that Induces Degradation of MYC Oncoprotein

      This technology is a development drug lead aiming to meet the medical needs of patients with small cell lung cancer. Through disturbing MYC-Aurora A interaction and inducing degradation of MYC oncoprotein, this bioavailable kinase inhibitor could serve as a potential treatment entity for SCLC.
    • Novel Therapy for Critical Limb Ischemia

      Precision Health Ecosystem FutureTech Novel Therapy for Critical Limb Ischemia

      We used the concepts of tissue regeneration, embedding drugs in biomaterial carriers,a rigorous regeneration deficient animal model with severe hind limb ischemia to develop an effective novel therapy Grace-001. The new drug can promote neovascularization, tissue regeneration, blood flow maintenance,restoration of blood vessels, nerves,muscles as well as their functions. This new dr
    • First-in-class anti-diabetic drug, PS1

      Precision Health Ecosystem FutureTech First-in-class anti-diabetic drug, PS1

      Diabetes is now still an incurable disease. Beta cell failure is one of common causes. No drugs for this failure have been developed. This invention is to developapply PS1 to treatreverse diabetes. PS1 is a first-in-class small-molecule drug, which targets beta cells by improving their survivalfunction. As a result, PS1 can treatreverse diabetes. The anti-diabetic mechanism of
    • Low-dose nanoscale biomimetic cell structure – Next-generation platform technology for advanced precision immunotherapy

      Precision Health Ecosystem FutureTech Low-dose nanoscale biomimetic cell structure – Next-generation platform technology for advanced precision immunotherapy

      We developed a biomimetic triple-antibody-immobilized magnetic fucoidan nanomedicine as a multifunctional artificial antigen presenting cell, which possessed the ability to not only inhibit immune checkpoint but activate tumor infiltrated T cells. of Bridging sites with tunable density on the nanoplatform was designed, allowing the antibodies to be well-distributed on the surface for mimicking immune cells. In contrast to the complex cell expansion process using microbeads in adaptive cell therapy, the nanoplatform can be i.v. administrated to cut the course of therapy from several weeks to days. With the development of the platform technology, an artificial immune system family can be built to pave the way for personalized immunotherapy.
    • Intelligent image-guiding needle puncture

      Precision Health Ecosystem FutureTech Intelligent image-guiding needle puncture

      Optical coherence tomography using an optical probe with a diameter of 0.9 mm, combined with the 14-18 gauge needle, is used for clinical needle puncture. Using the real-time image obtained from the tip of the needle in the tissue, the needle position can be identified. Combined with artificial intelligence can achieve objective, accurate and automatic identification of the tissue, which has been successfully verified in anesthesia and laparoscopic surgery.
    • Influenza mucosal vaccine compositionpreparationapplication thereof

      Precision Health Ecosystem FutureTech Influenza mucosal vaccine compositionpreparationapplication thereof

      Provided is an influenza mucosal vaccine compositionpreparationapplication thereof. This composition contains an antigen fusion protein which includes an influenza virus antigena Type IIb heat-labile enterotoxin A subunit. Immunization with the antigen fusion protein induces cellularhumoral immune responses, including systemicmucosal immune responses, against a specific in
    • Germplasm Bank of Medicinal Coral Producing New Targeted Anti-cancer Agenttheir Aquaculture Technology Platform

      Precision Health Ecosystem FutureTech Germplasm Bank of Medicinal Coral Producing New Targeted Anti-cancer Agenttheir Aquaculture Technology Platform

      The present invention discloses the germplasm bank of medicinal coral producing new targeted anti-cancer agent and their aquaculture technology platform. The medicinal corals are collected in Kenting, located at the southern tip of Taiwan. In response to the unmet medical needs of new anti-cancer drugs, our research results will provide more diverse types of new drug targets and lead compounds in the "new drug development-new drug discovery and exploration period".
    • AI_Variant Prioritizer

      Precision Health Ecosystem FutureTech AI_Variant Prioritizer

      The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.
    • Infectious Disease Diagnosis and Water Quality Monitoring Using Nanomaterials Immobilized Paper and a Flow Controllable Microfluidic Device

      Precision Health Ecosystem FutureTech Infectious Disease Diagnosis and Water Quality Monitoring Using Nanomaterials Immobilized Paper and a Flow Controllable Microfluidic Device

      Here we present a portable microfluidic device that can perform immunoassay for infectious disease diagnosis or detect heavy metal ions in water samples. The device is composed of two major components: nanomaterials modified paper-based detection platform and semi-automated flow manipulator. A reusable 3D-printed device is used to hold a disposable detection pad that modified with functional nanomaterials for water quality monitoring or antibodies for disease diagnosis. Besides, the use of spring-containing 3D-printed syringes manipulates a large-volume sample without manual actuation. Meanwhile, by controlling the flow rate via the linked flow regulator at the syringe outlet, solutions can react stably with the paper platform, which provides detection and pre-concentration effects.
    • A High Frequency Ventilator and Electrical Impedance Tomography for Respiratory Treatment

      Precision Health Ecosystem FutureTech A High Frequency Ventilator and Electrical Impedance Tomography for Respiratory Treatment

      The high-frequency jet ventilator uses the solenoid valve and feedback techniques to control the operational parameters of the ventilator. The proposed dual-mode control mechanism allows dynamic adjustment of the tidal volume, pressure, and duration of ventilation simultaneously. The system has been verified in animal experiments and demonstrated a significant improvement in the gas exchange efficiency. Besides, the bioelectrical impedance measurement can provide real-time and accurate regional information of the lungs, which helps to monitor the patient’s condition during respiratory treatment. This work also adopts wireless communication and remote-control technology to reduce the risk of infection of medical professionals.
    • Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus-infected burn wounds in a swine model

      Precision Health Ecosystem FutureTech Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus-infected burn wounds in a swine model

      Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.
    • Digital self-injection-locked ultrasonic Doppler radar for accurate non-contact vital sign monitoring

      Precision Health Ecosystem FutureTech Digital self-injection-locked ultrasonic Doppler radar for accurate non-contact vital sign monitoring

      A highly sensitivelinear ultrasonic radar was realized using digital self-injection-locking (SIL) technique. It can remotely monitor the vital signs of a human in motion, which will be demonstrated in this expo by upgrading a low-cost ultrasonic radar for reverse parking to support high-value telemedical applications. In the future it will further combine phased-array technology to implement non-contact 4D ultrasound system, which will bring disruptive innovation to medical technologies.
    • A Novel “Platform Technology” in Surgical Hemostasis

      Precision Health Ecosystem FutureTech A Novel “Platform Technology” in Surgical Hemostasis

      A novel “Platform Technology” in surgical hemostasis, based on biodegradable polyurethane particles with anti-inflammatory and nerve repair, not only accelerates wound healing but also provides solutions for hemostasis during surgery, and improve biocompatibility and adverse of commercially hemostats to achieve the best patient care. Our first product is aimed to provide a hemostatic agent, use on the bleeding surface and deep, with additional functions to surgeons, which allows customers to shorten the operation time, reduce stay in the hospital, and reduce the chance of secondary surgery.
    • Building A Deep Learning-based Chest X-ray CADe Platform MedCheX

      Precision Health Ecosystem FutureTech Building A Deep Learning-based Chest X-ray CADe Platform MedCheX

      As we continue to face the rapid increase in confirmed Coronavirus cases around the world, we created an AI-based pneumonia detection platform for COVID-19. The system is able to automatically detect high-risk patients with pneumonia that will then send information to doctors. With that information, the doctors are then able to make follow-up decisions and provide a treatment plan after the diagnosis. In specific, doctors from the Department of Medical Imaging provided us thousands of positive and negative chest x-rays for pneumonia as a training set. Our system has already been tested with and adopted by doctors at the NCKU Hospital. The system achieved 95% accuracy to detect the pneumonia symptom, based on 1400 test images.
    • Rapid Detection of AIOT Platform for Food SafetyEpidemic Prevention

      Precision Health Ecosystem FutureTech Rapid Detection of AIOT Platform for Food SafetyEpidemic Prevention

      The innovative technology which is based on the unique biomimetic material, including immunomagnetic nanoparticles, aqueous extraction solvent,a portable IoT detection device promotes the detection speed, accuracy,precision of the target molecule. Featuring with the excellent ability of non-specific binding, this technology decreased the probability of false-negative/false-positive succe
    • A Non-Invasive AI Imaging Technique for Quick Risk Assessment of Stroke and Cardiovascular Diseases

      Precision Health Ecosystem FutureTech A Non-Invasive AI Imaging Technique for Quick Risk Assessment of Stroke and Cardiovascular Diseases

      This product is a novel risk assessment tool for carotid artery stenosis and stroke. This is a revolutionary healthcare technology using motion analysis and quantification to extract information from pulses for risk assessments. The entire process is completed by taking a short video clip aimed at the neck with only one simple click on any mobile devices or our apparatus, anywhere, anytime. In less than five minutes, the user receives an evaluation report indicating low to high stroke risk. Our product accuracy stands higher than 90% when compared to the clinical outcome. The future indications of this product can be extended to arrhythmia, venous fistula obstruction, etc. This product has the great potential to achieve our dream of “personalized mobile hospital” in the future world.
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