Technical Name 免疫反應為基礎的奈米藥物安全性檢測平台-奈米金調控巨噬細胞功能與Nrf2抗氧化反應
Project Operator National Central University
Project Host 羅月霞
Summary \"Establish an immunological-based platform for nano drug:1. Establish macrophages as an in vitro cell-based testing platform2. Safety assessmentimmunomodulatory effects of nano drugs3. Gold nanodots as a specific target of Nrf2 pathway against chronic diseases.\"
Technical Film
Scientific Breakthrough Nrf2 can act as a therapeutic target against chronic inflammatory diseases. Preclinical studies have demonstrated that the activation of Nrf2 has anti-inflammatory effects. We have established an immunological-based platform for nano drug. Gold nanodots had immunomodulatory activities in macrophages. This nanodots can effectively activate Nrf2, increase a variety of antioxidant enzymes,reduce oxidative stress. The findings showed that gold nanodots have potential applications against chronic inflammatory diseases via the Nrf2 pathway.
Industrial Applicability Using our immunological-based platform for nano drug, we first identify that this nanogold drug has immunomodulatory activity, which can regulate the Nrf2 downstream target antioxidant enzymeincrease the phagocytic ability in human macrophages. Therefore, the development of a customized immunological-based platform for nano drug can discover the future potential applications of nano-drug-targeted immune cells.
Matching Needs 天使投資人、策略合作夥伴
Keyword Nano drug Immunomodulatory activities Macrophage Immunological-based platform Anti-inflammation Antioxidant Gold nanodots
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