Technical Name Virus and Cell Culture Platform for Vaccine Production Technology
Project Operator Research Center for Animal Biologics
Project Host 莊秀琪
Summary The \"Viral Vaccine Cell Production Technology Platform\" of this exhibition is based on 1. Host cell and virus match and colonization technology; 2. Cell-expressed virus receptor technology; 3. Blocking antiviral mechanism of host cell; 4. Immortalization technology of host cell; 5. Serum-free suspension cell culture technology to produce high-immunity virus vaccine strains containing intact virus antigens.
Technical Film
Scientific Breakthrough Through gene editing and transfection, these techniques block the host cell’s antiviral mechanism, and let the host cells express the specific virial receptor, reduce the immune response and apoptosis after virus infection, and provides rapid propagation of the virus. This technique strengthens the susceptibility of host cells to viruses, increases virus productivity, and produces intact antigens for production of commercial vaccines. These techniques can effectively increase productivity (market technology/ high performance cell production virus system), such as pseudorabies virus (10^7.5/10^10), porcine infectious diarrhea virus (10^4.5/10^8.5), very virulent infectious bursal disease viruses (10^3.5/10^8.5), Newcastle virus (10^7.5/10^9.5), avian reovirus (10^6.5/10^8.5).
Industrial Applicability The industrial application is as follows: 1. Manufacturing various vaccines. 2. Reducing the cost of vaccine preparation. 3. Virus production with high efficiency: The data shows that it can increase the output by 1000 times than other virus production methods. 4. Industrialization: This technology has been successfully applied to vaccine manufacturing. 5. Low pollution: This process uses culture virus without adding animal serum to diminish possible pollution in the vaccine production. 6. Rapid vaccine production responses to acute animal or human epidemics. 7. Development of antiviral drug screening platform is based on this technique. 8. It adapts animal welfare and humanitarianism and conducive to technology promotion.
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