Technical Name Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus-infected burn wounds in a swine model
Project Operator Marine Research Station, Institute of CellularOrganismic Biology, Academia Sinica
Project Host 陳志毅
Summary Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.
Technical Film
Scientific Breakthrough 1. We have demonstrated that epinecidin-1 exerts potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (a MDR clinical isolate). The use of epinecidin-1 may complement the use of antibiotics. AMPs are unlikely to induce resistance.2. Treatment with epinecidin-1 significantly reduces MRSA infection in pig model of wound infection compared to untreated controls and pig treated with conventional antibiotics. Given the prophylactic efficacy of Epi-1 and its inability to engender resistance, this AMP may be suitable for situations in which there is a high risk of infection.3. Our model is valuable for future research on the pathophysiology of wound healing and testing new therapeutics for the treatment of bacterial infections during porcine wound healing.
Industrial Applicability Our results demonstrated that the epinecidin-1 peptide promotes epithelial wound healing under in vitro conditions and effectively heals MRSA-infected wounds in a pig model. Application of epinecidin-1 can be in the area:1. Anti-infective, wound healing2. Acne catheter-related infections3. Infections of diabetic foot ulcers4. Oral candidiasis5. Vulvo-vaginal candidiasis6. Infectious complications of trauma and surgery7. Anti-endotoxin and fungal infections8. Systemic anti- pneumococcal infections
Keyword antimicrobial peptide grouper (Epinephelus coioides) fire burn wound healing Staphylococcus aureus cosmetics scar drug-resistant epinecidin-1 Methicillin-resistant Staphylococcus aureus
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