Technical Name Glycan-maskingglycan-unmasking hemagglutinin antigens for universal influenza vaccine development
Project Operator National Tsing Hua University
Project Host 吳夙欽
Summary The invention provides a glycan-masking and/or glycan-unmasking hemagglutinin, wherein the glycosylation site(s) is added on globular headremoved on stem. The glycan-masking and/or glycan-unmasking hemagglutinin may induce neutralizing antibody against influenza virus,cross-reactive protection against different virus. The invention also provides a method for manufacturing these antigens.
Scientific Breakthrough The invention provides a glycan-masking and/or glycan-unmasking hemagglutinin, wherein the glycosylation site(s) is added on globular headremoved on stem. The glycan-masking and/or glycan-unmasking hemagglutinin may induce neutralizing antibody against influenza virus,cross-reactive protection against different virus. The invention also provides a method for manufacturing these antigens.
Industrial Applicability The market for seasonal influenza vaccines, sized at US$2.8 billion in 2008–2009 across the major markets, not including the potential of pandemic vaccines. The annual rate of influenza vaccine is approximately 12.6. Our invention provides a glycan-masking and/or glycan-unmasking hemagglutinin antigen design, which can be further used for developing “universal influenza vaccines\".
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