Technical Name Glycan-maskingglycan-unmasking hemagglutinin antigens for universal influenza vaccine development
Project Operator National Tsing Hua University
Project Host 吳夙欽
Summary The invention provides a glycan-masking and/or glycan-unmasking hemagglutinin, wherein the glycosylation site(s) is added on globular headremoved on stem. The glycan-masking and/or glycan-unmasking hemagglutinin may induce neutralizing antibody against influenza virus,cross-reactive protection against different virus. The invention also provides a method for manufacturing these antigens.
Scientific Breakthrough The invention provides a glycan-masking and/or glycan-unmasking hemagglutinin, wherein the glycosylation site(s) is added on globular headremoved on stem. The glycan-masking and/or glycan-unmasking hemagglutinin may induce neutralizing antibody against influenza virus,cross-reactive protection against different virus. The invention also provides a method for manufacturing these antigens.
Industrial Applicability The market for seasonal influenza vaccines, sized at US$2.8 billion in 2008–2009 across the major markets, not including the potential of pandemic vaccines. The annual rate of influenza vaccine is approximately 12.6. Our invention provides a glycan-masking and/or glycan-unmasking hemagglutinin antigen design, which can be further used for developing “universal influenza vaccines\".
Keyword influenza vaccine universal neutralizing antibody hemagglutinin glycan masking glycan unmasking globular head stem region antigen design vaccine design
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