Technical Name Multivalent adenoviral vector-based vaccine against hand-food-mouth disease
Project Operator National Health Research Institutes
Project Host 周彥宏
Summary We developed a recombinant adenovirus Ad-HFMD vaccine which can express virus-like particles (VLPs) of EV71 capsid proteins. Mouse studies showed that Ad-HFMD can induce the protective antibodycellular immunity against EV71CVA16 in hSCARB2 transgenic (hSCARB2-Tg) mouse challenge model.
Market Potential Analysis 目前研發的FI-EV71疫苗:只能針對腸病毒71型,對克沙奇病毒無效。市場尚無類似多價疫苗產品,因此對於預防腸病毒71型及克沙奇病毒引起的手足口病的市場潛力很大。
Industrial Applicability 1.Ad-HFMD as a multivalent vaccine against EV71CVs-induced hand-food-mouth-disease2.Route of Ad-HFMD immunization are multiple including intranasal, musclesubcutaneous injection to induce anti-EV71CV immunity.
Keyword Enterovirus coxsackieviruses HFMD multivalent vaccine VLP adenovirus mucosal SCARB2 transgenic mice
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