技術簡介
「病毒疫苗細胞生產技術平台」以1.宿主細胞及病毒之選殖技術、2.宿主細胞表現病毒接受體技術、3.阻斷宿主細胞抗病毒機制、4.初代宿主細胞永生化技術、5.細胞無血清全懸浮培養技術,生產含完整病毒抗原之高免疫效力病毒疫苗株。
The "Viral Vaccine Cell Production Technology Platform" of this exhibition is based on 1. Host cell and virus match and colonization technology; 2. Cell-expressed virus receptor technology; 3. Blocking antiviral mechanism of host cell; 4. Immortalization technology of host cell; 5. Serum-free suspension cell culture technology to produce high-immunity virus vaccine strains containing intact virus antigens.

技術之科學突破性
以基因編輯與轉殖技術有效阻斷宿主細胞抗病毒機轉,同時讓宿主細胞表現細胞表面專一性病毒受體蛋白,有效降低病毒接種後免疫反應與細胞凋亡,提供病毒快速繁殖之細胞內環境,強化宿主細胞對病毒之易感性,有效提升病毒生產力價,生產具完整抗原之病毒顆粒,供工業化疫苗量產使用。
Through gene editing and transfection, these techniques block the host cell’s antiviral mechanism, and let the host cells express the specific virial receptor, reduce the immune response and apoptosis after virus infection, and provides rapid propagation of the virus. This technique strengthens the susceptibility of host cells to viruses, increases virus productivity, and produces intact antigens for production of commercial vaccines. These techniques can effectively increase productivity (market technology/ high performance cell production virus system), such as Pseudorabies virus (10^7.5/10^10), Porcine infectious diarrhea virus (10^4.5/10^8.5), Very virulent infectious bursal disease viruses (10^3.5/10^8.5), Newcastle virus (10^7.5/10^9.5), Avian reovirus (10^6.5/10^8.5).

技術之產業應用性
「病毒疫苗細胞生產技術平台」之產業應用性如下: 1.可應用於各種疫苗製備。2. 降低疫苗製備成本。3.高效率生產病毒。4.可技術產業化。5. 製程低汙染。6. 迅速有效投入疫苗生產。7.開發抗病毒藥物篩選平台。8. 取代動物犧牲符合動物福祉與人道主義利於技術推廣至歐美等先進國家。
The industrial application is as follows: 1. Manufacturing various vaccines. 2. Reducing the cost of vaccine preparation. 3. Virus production with high efficiency: The data shows that it can increase the output by 1000 times than other virus production methods. 4. Industrialization: This technology has been successfully applied to vaccine manufacturing. 5. Low pollution: This process uses culture virus without adding animal serum to diminish possible pollution in the vaccine production. 6. Rapid vaccine production responses to acute animal or human epidemics. 7. Development of antiviral drug screening platform is based on this technique. 8. It adapts animal welfare and humanitarianism and conducive to technology promotion.
 
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