Technical Name Fast Cancer Screening and Prognosis Assessment and Prediction of Treatment Response in Chronic Kidney Disease by Using Synchrotron Infrared Microscopy
Project Operator National Synchrotron Radiation Research Center
Project Host 李耀昌 副研究員
Summary 1. Infrared wax physisorption kinetics (iR-WPK) provides a glyco-histopathological imaging analysis for examining tissue sections, which utilizes n-alkanes with carbon number (CN) from 20 to 34 and beeswax as glycan adsorbents for targeting similar longitudinal length of glycans of glycoconjugates anchoring in the cell surface. 2. It is an in-situ non-destructive method of examining tissue sections for cancer screening and prognosis prediction for chronic kidney disease by profiling aberrant glycans covalently-attached to both glycoconjugates anchored in tissue sections. 3. It can screen ten cancers including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer.
Technical Film
Scientific Breakthrough 1. Infrared wax physisorption kinetics (iR-WPK) can provide an in-situ non-destructive glyco-histopathological imaging analysis at the spatial resolution of 10 × 10 um2  for cancer screening and prognosis prediction for chronic kidney disease diagnosis by detecting the distribution of the population ratio of aberrant to regular glycans respectively attached to glycoconjugates anchored in the cell surface and immune complex deposited onto glomerulus. 2. iR-WPK is useful for screening ten cancers, including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer. Single detection at room temperature (28°C) takes only 6~15 minutes.
Industrial Applicability 1. Infrared wax physisorption kinetics (iR-WPK) can provide an in-situ non-destructive glyco-histopathological imaging analysis at the spatial resolution of 10 × 10 um2 for cancer screening and prognosis prediction for chronic kidney disease diagnosis by detecting the distribution of the population ratio of aberrant to regular glycans respectively attached to glycoconjugates anchored in the cell surface and immune complex deposited onto glomerulus. 2. iR-WPK is useful for screening ten cancers including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer. Single detection at room temperature (28°C) takes only 6~15 minutes.
Matching Needs -
Keyword Infrared wax physisorption kinetics (iR-WPK) n-alkane beeswax glycan adsorbent glycoconjugates iPathologist glyco-histopathological analysis
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